Vascular actions of calcimimetics: role of Ca²⁺‐sensing receptors versus Ca²⁺influx through L‐type Ca²⁺channels

Abstract

Cinacalcet and calindol are potent arterial relaxants. Under the experimental conditions used, they predominantly act by inhibiting Ca²(+) influx through L-type Ca²(+) channels into vascular smooth muscle, whereas Ca²(+) -sensitive receptors (CaR or GPRC6A) play a minor role.