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An <i>in Vitro</i> Primary Immune Response to 2, 4, 6-Trinitrophenyl Substituted Erythrocytes: Response against Carrier and Hapten
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1970
Year
Clinical ImmunologyLaboratory ImmunologyImmune RegulationImmunologyVitro ResponseImmunologic MechanismBlood CellInnate ImmunityImmune SystemImmunotherapyInflammation6-Trinitrophenyl Substituted ErythrocytesHematologySpleen Cell SuspensionsTrinitrophenyl DeterminantAllergyGranulocyteAutoimmunityHumoral ImmunityImmune FunctionCell BiologyImmune Cell DevelopmentMedicine
Summary We have observed an in vitro response to the trinitrophenyl determinant (TNP) when spleen cell suspensions from unimmunized mice were cultured with the trinitrophenyl group coupled to sheep erythrocytes (TNP-SRBG) as immunogen. The response was measured by a progressive increase in the number of hemolytic plaque-forming cells assayed with TNP coupled to non-cross-reacting burro erythrocytes.