Abnormal Myocardial Contraction in α1A– and α1B–adrenoceptor double-knockout mice

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

Michael R. Bristow, Robert Ginsburg, Wayne Minobe et al. · New England Journal of Medicine · 1982 · 2.3K citations

Medicine, Cardiology, Physiology +14

Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group · JAMA · 2000 · 1.5K citations

Pharmacy, Cardiology, Pharmacotherapy +16

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

M D Feldman, L Copelas, Judith K. Gwathmey et al. · Circulation · 1987 · 487 citations

Medicine, Cardiology, Pharmacology +17

Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.

Paul Simpson · Circulation Research · 1985 · 485 citations · Full text

Life Sciences, Pharmacology, Physiology +13