Cu^II‐Promoted Aerobic Cascade Reactions of 2‐Alkynylanilines with Methyl Perfluoroalk‐2‐ynoates: En Route to 4‐Carbonyl‐2‐perfluoroalkylquinolines

Abstract

Abstract Using air as the oxygen source, 4‐carbonyl‐2‐perfluoroalkylquinolines were prepared in good to excellent yields, from readily available 2‐alkynylanilines and methyl perfluoroalk‐2‐ynoates through a Cu II ‐promoted sequential process that omits the isolation of the enamine intermediates. The reaction tolerates several useful functionalities including ether, ester and chloro substituents.