Concepedia
Epilepsia · 2010 · 123 citations · 29 references
Open access
These results support the hypothesis of local drug metabolism at the diseased BBB. The direct association between BBB CYP enzymes and the drug-resistant phenotype needs to be further investigated.
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CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes
Gang Luo, Mark R. Cunningham, Sean Kim et al. · Drug Metabolism and Disposition · 2002 · 446 citations
Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy
Stephen M. Dombrowski, Shailesh Y. Desai, Matteo Marroni et al. · Epilepsia · 2001 · 426 citations
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
Valérie Rigau, Matthieu Rousset, Frédéric de Bock et al. · Brain · 2007 · 418 citations · Full text
Blood-brain Barrier Permeability, Temporal Lobe Epilepsy, Vascular Density +17
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier
Sandrine Dauchy, Fabien Dutheil, Richard Weaver et al. · Journal of Neurochemistry · 2008 · 319 citations · Full text
Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies
Luca Cucullo, Pierre‐Olivier Couraud, Babette Weksler et al. · Journal of Cerebral Blood Flow & Metabolism · 2007 · 264 citations