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<i>In Vitro</i> studies with “Transfer Factor”: Transfer of the Cell-Migration Inhibition Correlate of Delayed Hypersensitivity in Humans with Cell Lysates from Humans Sensitized to Histoplasmin, Coccidioidin, or PPD
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1969
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ImmunohematologyLaboratory ImmunologySpecific Cell LysatesImmunodeficienciesCellular ImmunologyImmunologyImmune RegulationSpecific AntigenDermatologyImmune SystemImmunotherapyGuinea Pig MacrophagesCellular PhysiologyHypersensitivityInflammationCell-migration Inhibition CorrelateCell LysatesImmune MediatorCell SignalingIntrinsic ImmunityAllergyAutoimmunityHumoral ImmunityImmune FunctionTolerance InductionDelayed HypersensitivityCell BiologyPhagocyteSignal TransductionImmunosuppressionMedicine
Abstract When “nonsensitive” cells from skin test negative donors were incubated with specific antigen and specific cell lysates obtained from strongly skin test-positive histoplasmin, coccidioidin, or tuberculin skin test donors, the “nonsensitive” cells were “sensitized” and liberated a substance which specifically inhibited the migration of guinea pig macrophages. Cell lysates, antigen, or nonspecific combinations of both, either in the presence or absence of “nonsensitive” cells, failed to inhibit the migration of guinea pig macrophages.