Topical Anti‐inflammatory Activity of New 2‐(1‐Indolizinyl)propionic Acid Derivatives in Mice

Abstract

New 2-(1-indolizinyl)propionic acid derivatives were investigated using the croton oil ear test to determine their topical anti-inflammatory activity. The new compounds and the reference, indomethacin, were tested at a dose of 250 μg/ear and significantly inhibited (P <0.01) mouse ear oedema. The dose-response curves of the two most potent derivatives were established and the IC50 values obtained were compared with indomethacin to assess the relative anti-inflammatory activity. They were 0.23, 0.50 and 0.16 μmol/ear, respectively. These indolizine derivatives are potentially useful anti-inflammatory agents with similar activity to indomethacin.