Concepedia

Pharmacokinetic-Pharmacodynamic Modelling of Morphine Transport Across the Blood-Brain Barrier as a Cause of the Antinociceptive Effect Delay in Rats—A Microdialysis Study

M. René Bouw, Marie Gårdmark, Margareta Hammarlund‐Udenaes

Pharmaceutical Research · 2000 · 104 citations · 27 references

DOI

References

27

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to <i>d</i>‐tubocurarine

Lewis B. Sheiner, Donald R. Stanski, Samuel Vožeh et al. · Clinical Pharmacology & Therapeutics · 1979 · 1.1K citations

Xpose—an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

E. Niclas Jonsson, Mats O. Karlsson · Computer Methods and Programs in Biomedicine · 1998 · 998 citations

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Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection

William H. Oldendorf, Susan Hyman, Leon D. Braun et al. · Science · 1972 · 358 citations

, , +22

The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in <i>mdr1a</i> (−/−) and <i>mdr1a</i> (+/+) mice

Rujia Xie, Margareta Hammarlund‐Udenaes, Albertus G. de Boer et al. · British Journal of Pharmacology · 1999 · 203 citations · Full text

Drug Equilibration Across the Blood—Brain Barrier-Pharmacokinetic Considerations Based on the Microdialysis Method

Margareta Hammarlund‐Udenaes, Lennart Paalzow, Elizabeth C. M. de Lange · Pharmaceutical Research · 1997 · 176 citations