Lack of N-hydroxy-2-acetylaminofluorene sulfotransferase activity in the mammary gland and Zymbal's gland of the rat.

Abstract

Summary The O -sulfonate of N -hydroxy-2-acetylaminofluorene was not formed in vitro in the mammary gland or in the sebaceous gland of the external auditory canal (Zymbal9s gland), tissues of the rat that are highly susceptible to carcinogenesis by 2-acetylaminofluorene and N -hydroxy-2-acetylaminofluorene. Consequently, the O -sulfonate of N -hydroxy-2-acetylaminofluorene, reported to be an ultimate reactive metabolite of these carcinogens in male rat liver, does not appear to be involved in the mechanism of carcinogenesis in all tissues of the rat in which tumors are induced by these compounds.