CHANGES IN CONNECTIVE TISSUE REACTION INDUCED BY CORTISONE

Abstract

Article1 September 1952CHANGES IN CONNECTIVE TISSUE REACTION INDUCED BY CORTISONER. H. EBERT, W. R. BARCLAYR. H. EBERTSearch for more papers by this author, W. R. BARCLAYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-506 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCortisone and adrenocorticotropic hormone (ACTH) have a profound effect on a variety of inflammatory reactions, including acute and chronic infections,1, 2wound healing,3the Shwartzman phenomenon,4chemical irritation5and thermal burns.6In an effort to elucidate the nature of the changes which occur during cortisone therapy, a series of in vivo studies was undertaken using the rabbit ear chamber technic. Since earlier work in this laboratory using the rabbit ear chamber technic as an in vivo method of observation had provided insight into the dynamics of certain inflammatory reactions and hypersensitive states, it was felt that a study of the...Bibliography1. MogabgabThomas WJL: The effects of cortisone on bacterial infection, J. Lab. and Clin. Med. 39: 271, 1952. MedlineGoogle Scholar2. SpainMolomut DMN: Effects of cortisone on the development of tuberculous lesions in guinea pigs and their modification by streptomycin therapy, Am. Rev. Tuberc. 62: 337, 1950. MedlineGoogle Scholar3. HowesPlotzBluntRagan ELCMJWC: Retardation of wound healing by cortisone, Surgery 28: 177, 1950. MedlineGoogle Scholar4. ShwartzmanSchneiersonSofer GSSLJ: Suppression of the phenomenon of local tissue reactivity by ACTH, cortisone and sodium salicylate, Proc. Soc. Exper. Biol. and Med. 75: 175, 1950. CrossrefMedlineGoogle Scholar5. JonesMeyer KSK: Inhibition of vascularization of the rabbit cornea by local application of cortisone, Proc. Soc. Exper. Biol. and Med. 74: 102, 1950. CrossrefMedlineGoogle Scholar6. Whitelow NJ: The treatment of severe burns with ACTH. Preliminary case reports, Proc. Second Clinical ACTH Conference 2: 310, 1951. Google Scholar7. Sandison JC: Transparent chamber of rabbit's ear, giving complete description of improved technic of construction and introduction and general account of growth and behavior of living cells and tissues as seen with the microscope, Am. J. Anat. 41: 447, 1928. CrossrefGoogle Scholar8. AhernBarclayEbert JJWRRH: Modification of the rabbit ear chamber technic, Science 110: 665, 1949. CrossrefMedlineGoogle Scholar9. ClarkHitchlerKirby-SmithRexSmith ERWJHTROJH: General observations on the growth of new blood vessels into standardized chambers in the rabbit's ear and the subsequent changes in the newly grown vessels over a period of months, Anat. Rec. 50: 129, 1931. CrossrefGoogle Scholar10. Cappell DF: Intravitam and supravital staining, J. Path. and Bact. 32: 595, 1929. CrossrefGoogle Scholar11. EbertWissler RHRW: In vivo observations of the vascular reactions to large doses of horse serum using the rabbit ear chamber technique, J. Lab. and Clin. Med. 38: 511, 1951. MedlineGoogle Scholar12. EbertAhernBloch RHJJRG: Development of tuberculous infection. In vivo observations in the rabbit ear chamber, Proc. Soc. Exper. Biol. and Med. 68: 625, 1948. CrossrefMedlineGoogle Scholar13. Ebert RH: In vivo observations on the effect of cortisone on experimental tuberculosis, using the rabbit ear chamber technique, Am. Rev. Tuberc. 65: 64, 1952. MedlineGoogle Scholar14. RichGregory ARJE: The experimental demonstration that periarteritis nodosa is a manifestation of hypersensitivity, Bull. Johns Hopkins Hosp. 72: 65, 1943. Google Scholar15. EbertWissler RHRW: In vivo observations of the effects of cortisone on the vascular reaction to large doses of horse serum using the rabbit ear chamber technique, J. Lab. and Clin. Med. 38: 497, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 24, 1952.From the Department of Medicine, University of Chicago.The work was sponsored from a grant from the United States Public Health Service. 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