KB‐R7943, an inhibitor of the reverse Na⁺/Ca²⁺exchanger, blocks N‐methyl‐D‐aspartate receptor and inhibits mitochondrial complex I

Abstract

KB-R7943, in addition to NCX(rev) , blocked NMDA receptors in cultured hippocampal neurons and inhibited complex I in the mitochondrial respiratory chain. These findings are critical for the correct interpretation of experimental results obtained with KB-R7943 and a better understanding of its neuroprotective action.