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THE WALWORTH, WISCONSIN, EPIDEMIC OF HISTOPLASMOSIS
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Burton A. WaisbrenParasitic DiseaseEpidemic HistoplasmosisPathologyDisease OutbreakInfectious Disease ControlAugust 1958Emerging Infectious DiseaseInfection ControlParasitologyInfectious Disease EpidemiologyHistopathologyClinical Infectious DiseaseEpidemic Of HistoplasmosisClinical MicrobiologyEpidemiologyEmerging Infectious DiseasesZoonotic DiseasePathogenesisClinical InfectionMedicine
Article1 August 1958THE WALWORTH, WISCONSIN, EPIDEMIC OF HISTOPLASMOSISKENNETH R. WILCOX JR., M.D., BURTON A. WAISBREN, M.S., M.D., JOHN MARTIN, M.D.KENNETH R. WILCOX JR., M.D., BURTON A. WAISBREN, M.S., M.D., JOHN MARTIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-388 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONOutbreaks of acute histoplasmosis are being recognized with increasing frequency. A recent article by Lehan and Furcolow1 summarizes reports of 38 epidemics in this country and three from foreign countries. Much useful information has been gained concerning the sources of and modes of infection with Histoplasma capsulatum from the study of these epidemics. The literature on histoplasmosis is adequately reviewed elsewhere 2-8 and will not be reviewed in detail in this presentation.This report is of an epidemic of acute histoplasmosis which has some unusual features. Exposure of various types to a single source of the organisms occurred over...Bibliography1. LehanFurcolow PHML: Epidemic histoplasmosis, J. Chron. Dis. 5: 489-503, 1957. CrossrefMedlineGoogle Scholar2. LehanFurcolow PHML: Proceedings of the Conference on Histoplasmosis, 1952, Public Health Monograph No. 39, U. S. Government Printing Office, Washington, D. C., 1956. Google Scholar3. SchwarzBaum JGL: The history of histoplasmosis, 1906 to 1956, New England J. Med. 256: 253-258, 1957. CrossrefMedlineGoogle Scholar4. SilvermanSchwarzLaheyCarson FNJMERP: Histoplasmosis, Am. J. Med. 19: 410-459, 1955. CrossrefMedlineGoogle Scholar5. Loosli CG: Histoplasmosis—some clinical, epidemiological and laboratory aspects, M. Clin. North America 39: 171-199, 1955. CrossrefGoogle Scholar6. 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HillCampbell GBCC: A further evaluation of histoplasmin and yeast phase antigens of Histoplasma capsulatum in the complement fixation test, J. Lab. and Clin. Med. 48: 255-263, 1956. MedlineGoogle Scholar19. SchubertAjelloStanfordGrant JHLSVO: Variations in complement fixation antigen production by different strains of Histoplasma capsulatum grown in two media, J. Lab. and Clin. Med. 41: 91-97, 1953. MedlineGoogle Scholar20. SchubertAjello JHL: Variation in complement fixation antigenicity of different yeast phase strains of Histoplasma capsulatum , J. Lab. and Clin. Med. 50: 304-307, 1957. MedlineGoogle Scholar21. AllanKoehlerStovall VJW: Yeast and mycelial phase titers of the complement fixation test for histoplasmosis. To be published. Google Scholar22. SteinbergJamborSuydam BAWPLO: Amphotericins A and B—two new antifungal antibiotics possessing high activity against deep-seated and superficial mycoses, Antibiotics Annual, 1955-56, pp. 574-578, Medical Encyclopedia, Inc., New York. Google Scholar23. LehanYatesBrasherLarshFurcolow PHJLCAHWML: Experiences with the therapy of sixty cases of deep mycotic infections, Dis. of Chest 32: 597-617, 1957. CrossrefMedlineGoogle Scholar24. WilcoxFeig.WaisbrenMartin KRMBAJ: Epidemiologic aspects of Walworth histoplasmosis outbreak. To be published. Google Scholar25. Edwards PQ: Personal communication. Google Scholar26. ZeidbergDillonGass LDARS: Some factors in the epidemiology of histoplasmin sensitivity in Williamson County, Tennessee, Am. J. Pub. Health 41: 80-88, 1951. CrossrefGoogle Scholar27. FurcolowSitterby MLJ: Further studies of the geography of histoplasmin sensitivity in Kansas and Missouri, J. Kansas M. Soc. 52: 584-588, 1951. MedlineGoogle Scholar28. SachsSmithFlemingFurcolow DRTDSML: The prevalence of positive reactions to tuberculin and histoplasmin in a rural Minnesota county, Am. J. Hyg. 62: 43-53, 1955. MedlineGoogle Scholar29. FellerFurcolowLarshLangmuirDingle AEMLHWADJH: Outbreak of unusual form of pneumonia at Camp Gruber, Oklahoma in 1944—follow-up studies implicating Histoplasma capsulatum as the etiologic agent, Am. J. Med. 21: 184-192, 1956. CrossrefMedlineGoogle Scholar30. LoosliProcknowTanziGraystonCombs CGJJFJTLW: Pulmonary histoplasmosis in a farm family—a three year follow-up, J. Lab. and Clin. Med. 43: 669-695, 1954. MedlineGoogle Scholar31. ChernissWaisbren EIBA: North American blastomycosis—a clinical study of 40 cases, Ann. Int. Med. 44: 105-123, 1956. LinkGoogle Scholar32. EdwardsPeeplesBerger LBWJAG: Prevalence of sensitivity to tuberculin and histoplasmin among high school students in Montgomery County, Maryland, Pediatrics 21: 389-396, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented in part at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 28, 1958.From the Department of Medicine of Marquette University Medical School, St. Joseph's Hospital, the Wisconsin State Board of Health and the Communicable Disease Center, Public Health Service, USDHEW.Requests for reprints should be addressed to Burton A. Waisbren, M.D., Assistant Clinical Professor of Medicine, Marquette University School of Medicine, 208 E. Wisconsin Ave., Milwaukee, Wisconsin. 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