Targeting mi<scp>R</scp>‐155 restores abnormal microglia and attenuates disease in <scp>SOD</scp>1 mice

Abstract

We found overexpression of miR-155 in the SOD1 mouse and in both sporadic and familial human ALS. Targeting miR-155 in SOD1 mice restores dysfunctional microglia and ameliorates disease. These findings identify miR-155 as a therapeutic target for the treatment of ALS.