SYNDROME OF MASKED HYPERPARATHYROIDISM

Abstract

Case Reports1 June 1956SYNDROME OF MASKED HYPERPARATHYROIDISMDONALD H. ATLAS, M.D., Ph.D., F.A.C.P., PETER GABERMAN, M.D., HERMAN L. EISENBERG, M.D.DONALD H. ATLAS, M.D., Ph.D., F.A.C.P.Search for more papers by this author, PETER GABERMAN, M.D.Search for more papers by this author, HERMAN L. EISENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-6-1195 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of alkalosis and renal insufficiency resulting from the vomiting of chlorides and the prolonged ingestion of milk and soluble alkalies in intractable peptic ulcer patients has appeared sporadically in the literature1, 2, 3since first described by Hardt and Rivers.4In some of these patients only a transient, reversible renal insufficiency developed, but in others generalized calcinosis with metastatic calcification of kidneys and other vital organs was noted, and a fatal uremia was not infrequent. Burnett5and his associates reported six cases of a new syndrome characterized by hypercalcemia without hypercalciuria or hypophosphatemia, with calcinosis, ocular lesions and...Bibliography1. BockusBank HLJ: Alkalosis and duodenal ulcer, M. Clin. North America 16: 143 (July) 1932. Google Scholar2. BrownEustermanHartmenRowntree GEGBHRLG: Toxic nephritis in pyloric and duodenal obstruction: renal insufficiency complicating gastric tetany, Arch. Int. Med. 32: 425 (Sept.) 1923. CrossrefGoogle Scholar3. Oakley W: Alkalosis arising in treatment of peptic ulcer, Lancet 2: 187 (July 27) 1935. CrossrefGoogle Scholar4. HardtRivers LLAB: Toxic manifestations following the alkaline treatment of peptic ulcer, Arch. Int. Med. 31: 171 (Feb.) 1923. CrossrefGoogle Scholar5. BurnettCommonAlbrightHoward CHRRFJE: Hypercalcemia without hypercalciuria or hypophosphatemia, calcinosis and renal insufficiency; a syndrome following prolonged intake of milk and alkali, New England J. Med. 240: 787 (May 19) 1949. CrossrefMedlineGoogle Scholar6. KirsnerPalmerHumphreys JBWLE: Morphologic changes in the human kidney following prolonged administration of alkali, Arch. Path. 35: 207-225 (Feb.) 1943. Google Scholar7. SawyerSolez WHC: Salt-losing nephritis simulating adrenocortical insufficiency, New England J. Med. 240: 210-215 (Feb. 10) 1949. CrossrefMedlineGoogle Scholar8. MurphySettimiKozokoff FDALNJ: Renal disease with salt-losing syndrome; a report of four cases of so-called "salt-losing nephritis," Ann. Int. Med. 38: 1160-1176 (June) 1953. LinkGoogle Scholar9. MillerFreemanHeath JMIWH: Calcinosis due to treatment of duodenal ulcer, J. A. M. A. 148: 198-199 (Jan. 19) 1952. CrossrefMedlineGoogle Scholar10. WermerKuschnerRiley PMEA: Reversible metastatic calcification associated with excessive milk and alkali intake, Am. J. Med. 14: 108 (Jan.) 1953. CrossrefMedlineGoogle Scholar11. ScholzScheifley DACH: Alkalosis, renal insufficiency and hypercalcemia secondary to the excessive intake of Sippy powders, J. Clin. Endocrinol. 14: 1074-1078 (Sept.) 1954. CrossrefGoogle Scholar12. CarpenterPautler HMEE: Hyperparathyroidism with renal insufficiency; report of a case confused with the "Burnett syndrome," New England J. Med. 250: 453-456 (Mar. 18) 1954. CrossrefMedlineGoogle Scholar13. GabermanAtlasKammerlingEhrlichIsaacs PDHEMLJ: Renal anoxia syndrome; a review and report of 22 cases, Ann. Int. Med. 35: 148-168 (July) 1951. LinkGoogle Scholar14. GutmanSwensonParsons ABPCWB: The differential diagnosis of hyperparathyroidism, J. A. M. A. 103: 87-94 (July 14) 1934. CrossrefGoogle Scholar15. Rogers HM: Parathyroid adenoma and hypertrophy of the parathyroid glands, J. A. M. A. 130: 22-28 (Jan. 5) 1946. CrossrefMedlineGoogle Scholar16. RogersKeatingMorlockBarker HMFRCGNW: Primary hypertrophy and hyperplasia of the parathyroid glands associated with duodenal ulcer, Arch. Int. Med. 79: 307-321, 1947. CrossrefGoogle Scholar17. Black BM: Hyperparathyroidism, 1953, Charles C Thomas, Springfield, Illinois. Google Scholar18. Milne J: Primary hyperparathyroidism, New England J. Med. 251: 393-395 (Sept. 2) 1954. CrossrefMedlineGoogle Scholar19. SchneiderRobinette RWAH: Diagnosis of obscure hyperparathyroidism, Cleveland Clin. Quart. 18: 66-71 (Apr.) 1951. (Quoted from: Black, B. M.: Hyperparathyroidism, 1953) Charles C Thomas, Springfield, Illinois. CrossrefGoogle Scholar20. Snapper I: Medical clinics on bone disease: a text and atlas, 1949, Interscience Publishers, New York. Google Scholar21. SimsWeltOrloffNeedham EALGJJW: Asymptomatic hyponatremia in pulmonary tuberculosis, J. Clin. Investigation 29: 1545-1557, 1950. CrossrefMedlineGoogle Scholar22. WalshHoward FBJE: Conjunctival and corneal lesions in hypercalcemia, J. Clin. Endocrinol. 7: 644-652, 1947. CrossrefMedlineGoogle Scholar23. AlbrightReifenstein FEC: Parathyroid glands and metabolic bone disease, 1948, Williams and Wilkins Co., Baltimore. Google Scholar24. DufaultTobias FXGJ: Potentially reversible renal failure following excessive calcium and alkali intake in peptic ulcer therapy, Am. J. Med. 16: 231-236 (Feb.) 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication January 7, 1955.From the Department of Medicine, The Chicago Medical School and The Mount Sinai Hospital of Chicago.Presented in abstract form at the Midwest Regional Meeting of The American College of Physicians at Milwaukee, Wisconsin, November, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMilk-Alkali Syndrome Associated with Calcium Carbonate Consumption: Report of 7 Patients with Parathyroid Hormone Levels and an Estimate of Prevalence Among Patients Hospitalized with HypercalcemiaThe Milk-Alkali Syndrome: Current ConceptsERIC S. ORWOLL, M.D.HYPERCALCÆMIC NEPHROPATHYMegaloblastic Anemia and Neurologic Disturbances Combined with Folic Acid DeficiencyThe Milk-alkali SyndromePeptic Ulcer in Primary Hyperparathyroidism An Analysis of Fifty-two CasesW. T. WILDER, M.D., BOY FRAME, M.D., F.A.C.P., W. S. HAUBRICH, M.D.Zur Klinik der Kalkstoffwechselstörungen des ErwachsenenaltersZur Histologie und Pathogenese der Nierenverkalkung (Nephrocalcinose und dystrophische Kalknephrose)PRIMARY HYPERPARATHYROIDISM DUE TO A PARATHYROID ADENOMA: ANTEMORTEM DIAGNOSIS WITH TERMINATION IN POSSIBLE ACUTE PARATHYROID HORMONE INTOXICATION*WILLIAM HOROWITZ, M.D., F.A.C.P, ARTHUR A. BERENBAUM, M.D.Das Zentralnervensystem bei Krankheiten der Drüsen mit innerer SekretionThe Milk-Alkali SyndromeCalcium and the Kidney 1 June 1956Volume 44, Issue 6Page: 1195-1210KeywordsHospital medicineHypercalcemiaHyperparathyroidismIngestionKidneysLesionsMilkPathogensPeptic ulcersVomiting ePublished: 1 December 2008 Issue Published: 1 June 1956 PDF downloadLoading ...