Pharmacokinetics and Biodistribution of Oligonucleotide Adsorbed onto Poly(isobutylcyanoacrylate) Nanoparticles After Intravenous Administration in Mice

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

Sudhir Agrawal, Jamal Temsamani, Jin Tang · Proceedings of the National Academy of Sciences · 1991 · 560 citations · Full text

Chain Length Extension, Biochemistry, Medicine +13

Substrate Specificity and Kinetics of Degradation of Antisense Oligonucleotides by a 3′ Exonuclease in Plasma

Paul S. Eder, Rene J. DeVine, John M. Dagle et al. · Antisense Research and Development · 1991 · 285 citations

Degradation of poly (isobutyl cyanoacrylate) nanoparticles

Vincent Lenaerts, Patrick Couvreur, Dominique Christiaens-Leyh et al. · Biomaterials · 1984 · 268 citations

Materials Science, Engineering, Nanomaterials +4

Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice.

G Schwab, Christine Chavany, Gérard Goubin et al. · Proceedings of the National Academy of Sciences · 1994 · 169 citations · Full text

Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense Oligonucleotides

Christine Chavany, Trung Le Doan, Patrick Couvreur et al. · Pharmaceutical Research · 1992 · 148 citations