Experimental allergic uveitis III. Manifestations produced in the guinea pig by immunization with homologous retina

Abstract

Following one injection of guinea pigs with 10 mg. homologous retina in adjuvant emulsion, the large majority developed uveitis within 3 weeks. The clinical signs and histological manifestations observed at onset and for several weeks thereafter, during which the disease progressed from an iridocyclitis to cyclitis and choroiditis, are described. The development of cytologic events in the uveal tract resembled those of delayed hypersemitivity, in which lymphocytes predominated in the early infiltrate and plasma cells in the subsequent infiltrate. Although morphologic alteration of the retina was observed in some animals, it did not occur until after there was extensive cellular infiltration of the choroid. The possible relationship of this model to that produced previously with uveal tissue is discussed.