Publication | Open Access
Sulfur-containing metabolites of 2,5,2',5'-tetrachlorobiphenyl, a major component of commercial PCB's.
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1976
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Secondary MetaboliteOrganic ChemistryMice FecesChemistryChemical ContaminantToxicologyToxicological AspectPersistent Organic PollutantBiochemistryEcotoxicologyChemical PollutionMetabolomicsCommercial PcbPharmacologyGas Chromatographic ExaminationExperimental ToxicologyHeterocyclicNatural SciencesForensic ToxicologyEnvironmental ToxicologyNew MetabolitesMedicine
The excretion of four new metabolites of 2, 5, 2', 5'-tetrachlorobiphenyl (TCB) in mice feces was revealed by gas chromatographic examination. Based on mass spectrometric data and syntheses, the structures of these metabolites were identified as 3-and 4-methyl-sulfonyl-2, 5, 2', 5'-TCB (I and II, respectively), and 3-and 4-methylthio-2, 5, 2', 5'-TCB (III and IV, respectively).