Durhamycin, a Pentaene Antifungal Antibiotic from <i>Streptomyces durhamensis</i> sp. n

Abstract

Durhamycin, derived from a previously undescribed soil isolate, is an apparently new antibiotic active against many of the fungi pathogenic for man and animals. Cultural and morphological characteristics and biochemical reactions of Streptomyces durhamensis are detailed. Methods of extraction of the antibiotic, physicochemical properties, antimicrobial spectrum, and results of mouse toxicity and protection tests are given.