Direct Arylation of Benzo[<i>b</i>]furan and Other Benzo‐Fused Heterocycles

Abstract

Abstract The direct arylation of benzo[ b ]furan, benzo[ b ]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2‐position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo‐fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[ b ]furan.