Publication | Open Access
Tortifoline, a novel (20S, 22R)-5.ALPHA.-cevanine alkaloid from Fritillaria tortifolia.
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1989
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Chinese Herbal DrugMedicinal ChemistryNatural Product SynthesisAbsolute ConfigurationBiochemistryBotanyMedicine-5.Alpha.-cevanine AlkaloidNatural SciencesNew D/e CisOrganic ChemistryPhytopharmacologyPhytochemicalPhytochemistryPharmacologyDrug DiscoveryDrug Analysis
A new D/E cis (20S, 22R, 25S)-20-deoxy-5α-cevanine alkaloid, tortifoline (1), was isolated from the Chinese herbal drug, "rakuri baimo"(dried bulbs of Fritillaria tortifolia). The structure of 1 was deduced from spectral data and its absolute configuration was confirmed by X-ray crystallographic analysis.