Inhalational anaesthetics and<i>n</i>‐alcohols share a site of action in the neuronal Shaw2 K_vchannel

Abstract

These observations strongly support a molecular model of a general anaesthetic binding site in the Shaw2 K(v) channel. This site may involve the amphiphilic interface between the S4S5 linker and the S6 segment, which plays a pivotal role in K(v) channel activation.