Destruction of Lymphocytes <i>in Vitro</i> by Normal Serum from Common Laboratory Animals

Abstract

Summary Normal serum from various animals has been shown to be toxic to lymphocytes and peritoneal exudate cells of various other animals. This toxicity could best be shown with fresh serum or in some cases only with fresh serum. Serum heated at 56°C for 30 min lost its activity in most instances. The activity lost upon storage or heating could not be completely restored by the addition of fresh homologous or autologous serum. Some particularly toxic combinations of serum-lymphocytes were: human-rabbit; human-mouse; rabbit-chicken; rabbit-rat; rat-chicken; chicken-rabbit; and chicken-guinea pig.