Reversal of ischemic mitochondrial dysfunction.

Abstract

Chlorpromazine pretreatment dissociates the effects of liver ischemia on mitochondrial function from the development of irreversible cell injury.In the present study, data are presented that 1) further document that chlorpromazine does not affect the reaction of liver mitochondria to ischemia; 2) relate many of the ischemia-induced mitochondrial alterations to the previously described loss of adenine nucleotide translocation and the presently described increased inner membrane permeability; and 3) show