SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS

Abstract

Case Reports1 February 1958SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESISA. STEPHEN CLOSE, M.D., YOSHIRA TAIRA, M.D., DAVID A. CLEVELAND, M.D., F.A.C.S.A. STEPHEN CLOSE, M.D., YOSHIRA TAIRA, M.D., DAVID A. CLEVELAND, M.D., F.A.C.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-2-421 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExtramedullary hematopoiesis, or myeloid metaplasia, is a frequently encountered condition, occurring usually in association with certain types of anemia. It is particularly prone to occur with anemia due to myelophthisis or myelosclerosis, and is usually thought of as a compensatory mechanism whereby extramedullary tissue attempts to compensate for a deficiency of the marrow. However, extramedullary hematopoiesis is found often in autopsy material from cases in which there is no detectable bone marrow deficiency. Cholesterolemia and arteriosclerosis (experimentally), and various toxins and infections, are also known to be capable of initiating extramedullary hematopoiesis.9, 12Regardless of the cause or causes, in...Bibliography1. Altschul R: Heterotopic blood formation in experimental cholesterol arteriosclerosis, Arch. Path. 44: 282-286, 1947. Google Scholar2. Blaisdell J: Extramedullary hematopoiesis in a retroperitoneal tumor, Arch. Path. 16: 643-648, 1933. Google Scholar3. Brannan D: Extramedullary hematopoiesis in anemias, Bull. Johns Hopkins Hosp. 41: 104-135, 1927. Google Scholar4. Dameshek W: Some speculations on the myeloproliferative syndromes, Blood 6: 372-375, 1951. CrossrefMedlineGoogle Scholar5. Dieterich H: Studien über extramedullare Blutbildung bei chirurgischen Erkrankungen, Arch. f. klin. Chir. 134: 166-175, 1925. Google Scholar6. GuinonSimon LLG: Sur un cas d' anemie infantile pseudoleucemique, Bull. Soc. pédiat. de Paris 11: 16-29, 1909. Google Scholar7. Hallez GL: Contribution a l' etude des anemies avec Splenomegalie chez le Nourrisson forme pseudo-leucemique, Nourrisson 8: 154-171, 1920, cited by Brannan.3 Google Scholar8. HuCash CHJR: Erosion of inner table of skull by hyperplasia of bone marrow in kala-azar, with extramedullary formation of blood on surface of dura, Far East. A. Trop. Med., Tr. Seventh Cong. (1927) 3: 80-84, 1930. Google Scholar9. Jordan HE: The transformation of adipose tissue to hemocytopoietic tissue, Anat. Rec. 59: 461-475, 1934. CrossrefGoogle Scholar10. Kampmeier OF: Hemopoietic foci in the wall of the thoracic duct, and the cellular constituents of its lymph stream in the human fetus, Am. J. Anat. 42: 181-211, 1928. CrossrefGoogle Scholar11. Kurihara M: Uber das Blutbildende Gewebe im der Dura Mater des Menschen und Kaninschens, Trans. Soc. Path. Jap. 25: 364-369, 1935. Google Scholar12. Petri E: Über Blutzellhende im Fettgewebe des Erwachsenen und ihre Bedeutung für die Nervbildung der weissen und roten Lymphknoten, Virchows Arch. f. path. Anat. 258: 37-51, 1925. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin*Received for publication June 26, 1956.From the Departments of Surgery and Pathology, Veterans Administration Hospital, Wood, Wisconsin, and Marquette University School of Medicine, Milwaukee, Wisconsin.Requests for reprints should be addressed to A. Stephen Close, M. D., Department of Surgery, Veterans Administration Center, Wood, Wisconsin. 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