Mitochondrial genome depletion dysregulates bile acid‐ and paracetamol‐induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells

Abstract

The Nrf2-mediated pathway is partly independent of ROS production. Nuclear translocation of Nrf2 is insufficient to up-regulate Mdr1, Mrp1 and Mrp4, which requires the participation of other regulatory element(s) whose activation in response to GCDCA and paracetamol is impaired in Rho cells and hence probably sensitive to ROS.