Biologic properties of rat antibodies. 3. Histamine release mediated by two classes of antibodies.

Abstract

Summary Two different classes of rat antibodies have been shown to mediate the i.p. antigen-induced release of histamine. The heat-stable antibodies, associated with IgG a , involved in histamine release could be clearly differentiated from heat-labile homocytotropic antibodies. Antibodies associated with IgG a have been previously shown to mediate the antigen-induced release of SRS-A. It was not possible to dissociate the two biologic activities associated with IgG a antibodies by physical means.