Proinsulin/C‐peptide ratio, glucagon and remission in new‐onset Type 1 diabetes mellitus in young adults

Abstract

Remissions after diagnosis of Type 1 diabetes were associated with lower proinsulin/C-peptide ratios, suggesting more efficient proinsulin processing, and tended to have lower glucagon release than non-remissions. This indicates that, in remission, the residual islets maintain a secretion of insulin and glucagon of benefit for control of hepatic glucose production.