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Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases.
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1992
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Accelerated nodulosis during MTX for RA is not rare, and occurs despite good clinical response of polyarthritis. Rheumatoid factor positivity is not a prerequisite. New nodules are small and preferentially located in the fingers. Recurrence after rechallenge with MTX suggests causality.