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Genetic control of immune response to glutamic acid, alanine, tyrosine copolymers in mice. I. Association of responsiveness to H-2 genotype and specificity of the response.
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1972
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HistocompatibilityGeneticsImmunologyImmunodominanceImmune SystemImmunotherapyHypersensitivityInflammationImmunogeneticsImmune ResponsivenessAllergyAutoimmune DiseaseMedicineMinimal ResponseSelf-toleranceHumoral ImmunityAutoimmunityH-2 GenotypeMolecular ImmunologyGat 10PathogenesisTyrosine CopolymersImmunoglobulin EGlutamic Acid
The immune responsiveness of 21 inbred and congenic strains of mice to two copolymers of L-glutamic acid, L-alanine and L-tyrosine, GAT 10 and GAT 4 , was investigated. Mice of the H-2 a , H-2 b , H-2 d and H-2 k histocompatibility alleles were responders to GAT 10 , whereas strains possessing the H-2 f , H-2 j , H-2 p , H-2 q , H-2 r , H-2 s and H-2 w histocompatibility alleles were nonresponders, indicating an association between immune responsiveness and the H-2 locus. Although the response to GAT 4 was also linked to H-2 locus as above, the P strain having the H-2 p allele produced a minimal response. The study of the specificity of the antibody produced with the cross-reacting polymers GA(T 2 ) and GT indicated that the recognition of the antigenic determinant is under separate genetic control.