Subcortical gray matter segmentation and voxel‐based analysis using transverse relaxation and quantitative susceptibility mapping with application to multiple sclerosis

Abstract

Automatic segmentation of iron-rich deep gray matter can be improved by incorporating QSM. Voxel-based evaluation yielded increased R2 * and QSM in MS subjects in all four nuclei studied with R2 *, benefiting the most from localized analysis over whole-structure measures.