The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.

TLDR

Previous attempts to classify phagocytic mononuclear cells—such as the macrophage, reticulo‑endothelial, and reticulo‑histiocyte systems—have proven inadequate in light of current knowledge. The authors propose a new classification of highly phagocytic mononuclear cells and their precursors, the mononuclear phagocyte system, which may be revised as new information emerges. The system includes promonocytes and precursors in bone marrow, circulating monocytes, and tissue macrophages, defined by shared morphology, function, origin, and kinetics, and excludes reticular, dendritic, endothelial, and fibroblast cells.

Abstract

There have been many attempts in the past to classify phagocytic mononuclear cells and to define the cell system they are considered to form-among these being the "macrophage system" of Metchnikoff, the "reticulo-endothelial system" of Aschoff, and the "reticulo-histiocyte system" proposed by Volterra and reintroduced by Thomas. None of these is entirely adequate in the light of present knowledge. In 1969, therefore, a group of workers proposed a new classification of all highly phagocytic mononuclear cells and their precursors in what they termed the "mononuclear phagocyte system". This system includes the promonocytes and their precursors in the bone marrow, the monocytes in the peripheral blood, and the macrophages in the tissues. Subsequent consultation with numerous other specialists throughout the world led to a certain number of changes in this classification, which is now proposed in revised form.Inclusion of cells in the "mononuclear phagocyte system" is based on similarities in the morphology, function, origin, and kinetics of the phagocytes. By these criteria reticular cells, dendritic cells, endothelial cells, and fibroblasts (fibrocytes) are excluded. The proponents point out that as new knowledge is acquired modifications may have to be made, certain cells being added to or removed from the new classification.