The role of HIF‐1, angiopoietin‐2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide‐associated actions: A pilot <i>in vivo</i> study

Abstract

HIF-1, Ang-2, Dll4 and Notch1 might participate in the formation of GIVM. Thalidomide is an effective and safe treatment agent for GIVM and its associated bleeding. The reduction degree of Ang-2 after a 4-month treatment of thalidomide may offer values for evaluating its prognosis and efficacy.