Human low‐molecular‐mass kininogen

Abstract

The complete amino acid sequence of the human low-molecular-mass kininogen light chain has been determined. The peptide chain contains 38 amino acid residues. In position 18 the half-cystine residue which forms the disulfide bridge to the heavy chain was found. Alignment of the present sequence with other kininogen light chain sequences indicated that the amino-terminal part of it is species-specific and the carboxy-terminal part is function-specific. Statistically significant internal homologies between various parts of the low-molecular-mass kininogen sequence as well as homologies between parts of the sequences of kininogen and ribonucleases were observed.