Germline <scp><i>PTEN</i></scp>, <scp><i>SDHB‐D</i></scp>, and <scp><i>KLLN</i></scp> alterations in endometrial cancer patients with Cowden and Cowden‐like syndromes: An international, multicenter, prospective study

Abstract

Clinical predictors of PTEN and KLLN alterations, but not SDHx_var+, were identified. These predictors should alert the treating physician to potential heritable risk and the need for referral to genetic professionals. High-risk cancer surveillance and prophylactic surgery of the uterus may be considered for KLLN_Me+ patients similarly to PTEN_mut+ patients.