Synthesis of Some Novel 1,2,4‐Triazol‐3‐one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities

Abstract

A series of new 1,2,4‐triazole‐3‐one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, 1 H NMR, 13 C NMR, elemental analysis, and LC‐MS. The anticonvulsant activities of the compounds 4a – c , 4e , and 5a – e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock‐induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.