Baicalein ameliorates renal interstitial fibrosis by inducing myofibroblast apoptosis <i>in vivo</i> and <i>in vitro</i>

Abstract

The present findings show that baicalein can ameliorate tubulointerstitial fibrosis by inducing myofibroblast apoptosis through the mitochondrion-associated intrinsic pathway, which may be mediated by the inhibition of the phosphoinositide-3-kinase/Akt (PI3k/Akt) pathway.