Genomic Copy Number Variations of the Complement Component<i>C4B</i>Gene Are Associated With Chronic Central Serous Chorioretinopathy

Abstract

This study showed that copy numbers of C4B are significantly associated with cCSC. Carrying no copies of C4B significantly increases the risk of cCSC, whereas carrying three C4B copies is protective. These findings reinforce the hypothesis of a possible involvement of the complement system in the pathogenesis of cCSC.