The hydrogen sulfide donor, <scp>GYY</scp>4137, exhibits anti‐atherosclerotic activity in high fat fed apolipoprotein <scp>E</scp>^−/− mice

Abstract

GYY4137 inhibits lipid accumulation induced by ox-LDL in RAW 264.7 cells. In vivo, GYY4137 decreased vascular inflammation and oxidative stress, improved endothelial function and reduced atherosclerotic plaque formation in apoE(-/-) mice.