Genetic Deletion and Pharmacological Inhibition of PI3K<i>γ</i> Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis‐Like Lung Disease

Abstract

These results demonstrate the biological efficacy of both genetic deletion and pharmacological inhibition of PI3Kγ in reducing chronic neutrophilic inflammation in CF-like lung disease in vivo.