EXPRESSION OF CONCERN: H₂S‐donating sildenafil (ACS6) inhibits superoxide formation and gp91^phox expression in arterial endothelial cells: role of protein kinases A and G

Abstract

H(2)S inhibited O(2)(*-) formation and upregulation of NADPH oxidase in PAECs through the adenylyl cyclase-PKA pathway. ACS6 may be effective in treating ARDS through both elevation of cAMP and inhibition of phosphodiesterase type 5 activity.