<scp>JAK2/STAT5/Bcl‐xL</scp> signalling is essential for erythropoietin‐mediated protection against apoptosis induced in <scp>PC</scp>12 cells by the amyloid β−peptide <scp>Aβ<sub>25–35</sub></scp> - Concepedia

Concepedia

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<scp>JAK2/STAT5/Bcl‐xL</scp> signalling is essential for erythropoietin‐mediated protection against apoptosis induced in <scp>PC</scp>12 cells by the amyloid β−peptide <scp>Aβ<sub>25–35</sub></scp>

DOI Full Paper Access

57

Citations

33

References

2014

Year

Rong Ma, Jing Hu, Cheng-Fang Huang, Min Wang, Jizhou Xiang, Gang Li

British Journal of Pharmacology

Abstract

EPO protected PC12 cells against Aβ25-35 -induced neurotoxicity. Activation of JAK2/STAT5/Bcl-xL pathway was important in EPO-mediated neuroprotection. EPO may serve as a novel protective agent against Aβ25-35 -induced cytotoxicity in, for instance, Alzheimer's disease.

References

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