MYELOCYTIC LEUKEMIA: AN ANALYSIS OF INCIDENCE, DISTRIBUTION AND FATALITY, 1910-1948

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Article1 July 1951MYELOCYTIC LEUKEMIA: AN ANALYSIS OF INCIDENCE, DISTRIBUTION AND FATALITY, 1910-1948MICHAEL B. SHIMKIN, STACY R. METTIER, F.A.C.P., HOWARD R. BIERMANMICHAEL B. SHIMKINSearch for more papers by this author, STACY R. METTIER, F.A.C.P.Search for more papers by this author, HOWARD R. BIERMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-1-194 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLeukemia was established as a distinct clinical entity in the middle of the Nineteenth Century. As Forkner1 notes in his monograph a hundred years later, "We know almost nothing about its cause or its specific treatment."Potassium arsenite, radiation and benzol were known by 1915 to produce marked clinical remissions in myelocytic leukemia. During the past four years, three additional agents—ethyl carbamate, the amine mustards, and perhaps the antifolic acid compounds—have been reported to effect distinct clinical improvement in the course of the disease.2Adequate analyses of the final results of such therapy, in terms of longevity of patients with...Bibliography1. Forkner CE: Leukemia and allied disorders, 1938, Macmillan Co., New York, p. 333. Google Scholar2. ShimkinBierman MBHR: Experimental chemotherapy of neoplastic diseases, Radiology 53: 518-529, 1949. CrossrefMedlineGoogle Scholar3. MinotBuckmanIsaacs GRTER: Chronic myelogenous leukemia, J. A. M. A. 82: 1489-1494, 1924. CrossrefGoogle Scholar4. HoffmanCraver WJLF: Chronic myelogenous leukemia, J. A. M. A. 97: 836-840, 1931. CrossrefGoogle Scholar5. McAlpinGoldenEdsall KRRKS: The roentgen treatment of chronic leucemia, Am. J. Roentgenol. 26: 47-63, 1931. Google Scholar6. 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Scandinav. 132: 124-131, 1948. CrossrefGoogle Scholar14. Widmann BP: Results of roentgen treatment of leukemia, Am. J. Roentgenol. 55: 377-386, 1946. Google Scholar15. MoffittLawrence HCJH: Chronic leukemia of long duration with a report of 31 cases with a duration of over five years, Ann. Int. Med. 30: 778-790, 1949. LinkGoogle Scholar16. Gover M: Cancer mortality. In the United States Public Health Bulletin Nos. 248, 1939; 252, 257, 1940; 275, 1941. U. S. Public Health Service, Washington, D. C. Google Scholar17. Bureau of the Census, Mortality Statistics, 1910, 1920, 1930, 1935, 1940, 1944. Government Printing Office, Washington, D.C. Google Scholar18. SacksSeeman MSI: A statistical study of mortality from leukemia, Blood 2: 1-14, 1947. CrossrefMedlineGoogle Scholar19. Hueper WC: Environmental cancer, U. S. Public Health Report Suppl. 209, 1948. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication December 28, 1949.From the Laboratory of Experimental Oncology, National Cancer Institute, National Institutes of Health, U. S. Public Health Service, and the Department of Medicine, University of California Medical School, San Francisco, California. 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METTIER, F.A.C.P.ALKYLAMINES IN THE TREATMENT OF LEUKÆMIASome Practical Aspects of Cancer PreventionPericarditis in patients with leukemia 1 July 1951Volume 35, Issue 1Page: 194-212KeywordsMedical servicesPotassiumPrevention, policy, and public healthResearch laboratories ePublished: 1 December 2008 Issue Published: 1 July 1951 PDF downloadLoading ...