Rates of change and sensitivity to change in cartilage morphology in healthy knees and in knees with mild, moderate, and end‐stage radiographic osteoarthritis: Results from 831 participants from the osteoarthritis initiative

Abstract

MRI-based cartilage thickness showed high rates of loss in knees with moderate and end-stage radiographic OA, and small rates (indistinguishable from healthy knees) in mild radiographic OA. From the perspective of sensitivity to change, end-stage radiographic OA knees need not be excluded from longitudinal studies using MRI cartilage morphology as an end point.