PubMed · 1972 · 340 citations · 3 references
MedicinePlastic SurgerySurgeryMicrosurgeryTissue EngineeringWound HealingFlap SurgeryHeat InjuryOsteocutaneous FlapsRabbit SurgeryThermal Injury PathophysiologyThermal PhysiologyFlap PhysiologyFlapsHeat Transfer In TissuesOxygen Consumption KineticsOxygen Tension MeasurementThermal Injury AssessmentThermal Injury ResponseThermal Properties
The study measured oxygen consumption rates of granulation tissue from cylinders implanted in rabbit bipedicle tube flaps and skin fold controls over weeks 2–7 using a Biological Oxygen Monitor. Granulation tissue in flaps showed a progressive decline in oxygen consumption from week 2 to week 7, reaching very low levels, while control tissue maintained higher QO₂ at weeks 3, 4, 5, and 7.
The oxygen consumption rate (QO2) of granulation tissue from cylinders implanted in bipedicle tube flaps of rabbits was measured weeks 2 to 7 in vitro in a Biological Oxygen Monitor. Granulation tissue from cylinders implanted in skin folds was used as control. The QO2 of granulation tissue decreased slowly as the oxygen tension in the medium fell. All measurements were made at an oxygen tension of 75 mmHg. At week 2 the QO2 of granulation tissue in flaps was high and a decrease occurred between week 2 and week 4. A further decrease took place between weeks 6 and 7 and a very low QO2 was found at week 7. Control granulation tissue showed a higher QO2 than skin flap granulation tissue at weeks 3, 4, 5 and 7.
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Metabolic phases during the development of granulation tissue
Kirsti Lampiaho, E. Kulonen · Biochemical Journal · 1967 · 67 citations · Full text