Antinociceptive Activity of Trigonella foenum- graecum Leaves and Seeds (Fabaceae)

Abstract

Present study reports analgesic activity of petroleum ether, chloroform, ethyl acetate and methanolic extracts of leaves and seeds of Trigonella foenum-graecum Linn. (Fabaceae) using hot plate method for evaluation of central analgesic activity and acetic acid induced writhing test for evaluation of peripheral analgesic activity in mice. All the extracts of Trigonella foenum-graecum showed significant central and peripheral analgesic activity at the dose of 50 mg/kg intraperitoneally. Amongst all the extract methanolic extract of leaves of Trigonella foenum-graecum showed highest increase in reaction time in hot plate method and more inhibitory effect on writhing induced by acetic acid. Pentazocin and paracetamol was taken as standard drug for hot plate and writhing model respectively.