Studies on the chemotherapy of experimental brain tumors: development of an experimental model.

Abstract

A method of rapidly implanting tumors intracerebrally in large numbers of mice is described. Four tumors previously induced by carcinogen implantation into brains of mice were used. Histologically and biologically, they were gliomas (ependymoblastoma). The pathology of the tumors, their pathogenesis in the host brain, and the clinical course of tumor-bearing animals was evaluated. The average median day of death and the number of animals surviving longer than 60 days from failure of the tumor to take were determined and are presented. The advantages and disadvantages in the use of these animal systems in intracerebral tumor models are dis cussed.