Scutellariae radix. X. Inhibitory effects of various flavonoids on histamine release from rat peritoneal mast cells in vitro.

Abstract

The effects of various flavonoids isolated from the roots of Scutellaria baicalensis on the histamine release from mast cells were investigated. Many of the flavonoids (wogonin, wogonin-7-O-D-glucuronide, baicalein, skullcapflavone II, (2S)-2', 5, 6', 7-tetrahydroxyflavanone, (2R, 3R)-2', 3, 5, 6', 7-pentahydroxyflavanone and 2', 5, 5', 7-tetrahydroxy-6', 8-dimethoxyflavone) inhibited the histamine release from rat mast cells induced by compound 48/80.