HL-A antigens in solid tumors.

Abstract

The possible association of 23 HL-A specificities with susceptibility to cancer was investigated in a total of 1996 patients and 906 controls. Cancer patients whose cancers were subdivided into the broad location categories of bladder, breast, cervix, colon, endometrium, lung, lymphoma, melanoma, ovary, prostate, rectum, sarcoma, and stomach showed significant departure in some HL-A antigen frequencies from that of controls. In a series of 321 Hodgkin's disease patients, HL-A5 and W18 antigens were increased. Application of the most conservative statistical correction of p values, however, caused all differences to fall short of statistical significance.