Concepedia

Effects of MiRP1 and DPP6 β‐subunits on the blockade induced by flecainide of K<sub>V</sub>4.3/KChIP2 channels

Susanne Radicke, Luis M. Vaquero, Ricardo Caballero, Ricardo Gómez, Lucía Núñez, Juan Tamargo, Ursula Ravens, Erich Wettwer, Eva Delpón

British Journal of Pharmacology · 2008 · 25 citations · 25 references

DOIFull text

Open access

Abstract

Flecainide directly binds to the Kv4.3 alpha-subunit when the channels are in the open and inactivated state and the presence of the beta-subunits modulates the blockade by altering the gating function.

References

25

Modulation of A-type potassium channels by a family of calcium sensors

Wei An, Mark R. Bowlby, Maria Betty et al. · Nature · 2000 · 965 citations

, , +8

Role of the Kv4.3 K<sup>+</sup>Channel in Ventricular Muscle

Jane E. Dixon, Wenmei Shi, Hongsheng Wang et al. · Circulation Research · 1996 · 435 citations

Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin.

Erich Wettwer, G J Amos, Herbert Posival et al. · Circulation Research · 1994 · 362 citations · Full text

, , +15

The CD26-Related Dipeptidyl Aminopeptidase-like Protein DPPX Is a Critical Component of Neuronal A-Type K+ Channels

Marcela S. Nadal, Andrés Ozaita, Yimy Amarillo et al. · Neuron · 2003 · 356 citations · Full text

, , +12

Regulation of <i>KChIP2</i> potassium channel β subunit gene expression underlies the gradient of transient outward current in canine and human ventricle

Barbara Rosati, Zongming Pan, Steven Lypen et al. · The Journal of Physiology · 2001 · 281 citations · Full text