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Noyori's Hydrogenation Catalyst Needs a Lewis Acid Cocatalyst for High Activity We thank Mr. Christian Dambouwy, Thales Technologies AG, Zürich, Switzerland, for experimental work to compare the effects of various combinations of bases and salts. Additionally, we thank Mr. Holgar Sellner in the group of Prof. D. Seebach for assistance in ee measurements, and Sebastian D. Friess for carefully correcting the German version of this manuscript.
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2001
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EngineeringAmine LigandsOrganic ChemistryHydrogenation CatalystRuii ComplexesChemistryCatalyst ActivationEe MeasurementsChemical EngineeringOrganometallic CatalysisLewis Acid CocatalystInorganic ChemistryBiochemistryAlkali Metal CationsCatalysisHydrogenCatalytic ProcessNatural SciencesCoordination ComplexHeterogeneous CatalysisMolecular ComplexCatalyst Preparation
Alkali metal cations are indispensible cocatalysts for the high activity of RuII complexes with phosphane and amine ligands in the catalytic hydrogenation of ketones. The proposed mechanism (see scheme) is based on structural evidence as well as on the hydrogen-cleaving activity of other RuII complexes.